ST. LOUIS—Powerful storms roared through middle America again on Wednesday, with weak tornadoes touching down in isolated spots and severe thunderstorms threatening such strikes in several states.

The National Weather Service issued tornado watches and a series of warnings in a dozen states, stretching northwest from Texas through the Mississippi River valley to Ohio.

“Everybody’s working as fast and furious as possible,” said Beverly Poole, the chief meteorologist at the National Weather Service’s office in Paducah, Kentucky, which covers southeastern Missouri and southern Illinois. “This is just a wild ride.”

There were no immediate reports of deaths from the new round of storms, but authorities in southern Indiana reported several injuries when a tornado touched down east of Bedford.

Wednesday’s storms followed a deadly outbreak on Tuesday in Arkansas, Oklahoma and Kansas that killed at least 15 people. America’s single deadliest tornado since 1950 killed 125 on Sunday in the southwest Missouri city of Joplin. Heavy rains, hail and lightning pounded Memphis on Wednesday night as a tornado warning sounded. Menacing clouds showed some rotation, but there were no confirmed reports of tornadoes touching down.

Law-enforcement agencies reported one home destroyed late Wednesday afternoon in the rural Carter County town of Ellsinore, about 150 miles (240 kilometers) south of St. Louis. Earlier in the day, a tornado cut through the city of Sedalia about an hour later and damaged several homes and businesses, Pettis County Sheriff Kevin Bond said.

In Illinois high winds, rain and at least four possible tornadoes knocked down power lines and damaged at least one home and a number of farm buildings across the central and eastern parts of the state.

“Mostly it was shingles off roofs and garages,” said Illinois Emergency Management Agency spokesman Patti Thompson.